Possible Role of Cost-Effectiveness of HPV Vaccination within the Decision Context on Inclusion of HPV in the Country-Specific National Immunization Programs

Background: Vaccination against HPV presents a new primary prevention strategy against cervical cancer and is now being introduced in countries all over Europe. Health-economic modelling plays an increasingly important role in the decision making process when introducing new health-care technologies into national programmes. This study compares the economic evaluations used by European countries in the decision making process about the introduction of HPV vaccination in European countries and evaluate the role of these evaluations in this decision making process. Method: Publicly available reports from official government advisory and regulatory bodies were obtained and analysed in terms of their perspective, discount rate, time horizon, type of mathematical model, assumptions made regarding the vaccine and the current screening practice, sensitivity analysis, and outcome. Results: Health-economic studies were found for nine European countries. All analysed in the base-case analysis the costeffectiveness of vaccination of girls around the age of 12 year in addition to a cervical carcinoma screening program. Both static and dynamic models were used and especially assumptions regarding cost data varied widely among included studies. Estimated incremental cost-effectiveness ratios varied from 11, 400 to 64, 000 per life-year gained in the base cases. Results were most sensitive to the choice of discount rate, vaccine costs and duration of protection after